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Reversible Cell Injury


    Reversible cell injury :-

If ischemia or hypoxia is for short time duration then effect on cell can be reverting back to normal condition is called RCI.

·         Normal cell   


 Some condition we are seeing in biochemical  & ultra structural in the presence of RCI

1) decrease generation of cellular ATP

2) Intra cellular lactic acidosis

3) Damage to plasma membrane pumps

4) Reduced protein synthesis


(1) decreased generation of cellular ATP :-


All living cell require continuous supply of oxygen to produce oxygenated blood is also required for all cells.


 Ischemia  /hypoxia /O2 ↓

     ↓

Mitochondria affected

                ↓

Synthesis of ATP in the presence of oxidative phosphorylation

       ↓

↓Energy dependent process

       ↓

Decreased function of Na+ ,k+, ATP are pump in cell membrane

 

·         But when adequate O2 supply to cell then it can be reverting back to normal condition .


(2)Intra cellular lactic acidosis :-

                          Hypoxia O↓                                     anaerobic glycolycis        
                                                                                 ↓rapid deplection of glycogen

                                                                           ↑accumulation of lactic acid


              Intracellular lactic acidosis

                      ↓

             Decreased intracellular pH

                     ↓

             Nuclear clumping chromatin

                     ↓

             In RCI, only nuclear charges are seeing




(3) Damage of plasma membrane pump:-

 Cellular fatty acids which are required for continuous repair of cell membrane .

(a) failure function of Na+ k+ ATP are pump:-.


                                                         


(b)            Failure of Ca pump:-

Membrane damage cause disturbance in the calcium ion. exchange a cross the cell membrane.

                                                                      Ca-           Ca-

     Ca-                    Ca-

          Exam calcium move in cell

 

Particularly in mitochondria causing swelling & deposition of phaspholipid rich amorphous densities

 

4)Reduction of protein synthesis






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