Irreversible cell Injury

Irreversible cell Injury :-

⇨ Persistence of ischemia or hypoxia is caused the irreversible cell injury to damage structure and function of cells.

· ⇨ In this stage injured cell can not return to normal .

1) Damage to cell membrane function & plasma membrane :-

⇩

Reduction in ATP , depletion of protein reduced intra cellular pH & leakage of lysosomal enzyme into the plasma

⇩ Continued influx of water ⇩

Damage/loss of membrane phaspholipids & loss of protective amino acids (like glycine)

⇩

Damage of cell membrane ⇩ Massive influx of Ca.

2) Calcium Influx:-

Massive Ca++ influx (into mitochondria)

⇩

activation of many enzymes and large flocculent mitochondrial densities formation .

Nuclear change in IRCI:-

Activated endonucleases

⇩

Nuclear damage

Some specific term:-

(A) Pyknosis:- degeneration and condensation of nuclear chromatin.

Means:- breakdown of nuclear & stick to each other

(B) Karyorrhexix :- Nuclear fragmentation

Normal cell

Pyknosis

⇩

Karyorrhexis

⇩

Karyolysis

Cell death in three condition.

cell death in three conditiion .

AyurvedaPushpsabha