Skip to main content

Necrosis

 

         Necrosis:-

 

Definition:-

Necrosis is the series of morphological changes that follow cell death in lethally injured of living cells.

·          In which cellular membrane fall apart and cellular enzymes leak out and ultimately digest the cell.

·         Necrosis is caused by various agent such as hypoxia, chemical & physical agents ,microbial agent, immunological injury etc.

Types:-

Types of necrosis based on etiological &morphological appearance.

1) Coagulative Necrosis

2) Liquefactive Necrosis

3) Caseous Necrosis

4) Fat Necrosis

5) Fibrinoid Necrosis

1) Coagulative Necrosis :-

* This is the most common type of necrosis caused by irrversible cell injury.

* It’s mainly caused by sudden stop of blood flow and less often from bacterial &chemical agents.

* The organ commonly affected area are heart,kidney &spleen.

 * Denaturation of all protein and its own lysosomal enzymes are also denatured.

* Later dineted by Leukocytes. For exp- All infarcts expect brain.

2)Liquefactive Necrosis :-

* Tissue get converted into liquid viscous mass.

*It’s due to ischemic injury and fungal or bacterial infection.

*Hydrolytic enzymes caused to tissue degradation &  material become ; semi fluid material (creamy yellow pus ) for eg.- Brain infarets, & abscess cavity.

 3)Caseous Necrosis :-

* This type of Necrosis is found in the centre of foci of tuberculosis infections.

*It’s combine feature of both coagulative & liquefactive necrosis.

*It’s resemble like dry cheese (yellow white colour) soft & granular for eg.-Tuberculosis

4) Fat Necrosis:-

* Fat necrosis mainly occurs in fat rich anatomic location in the body like breast.

*Fat become fat distruction ; calcified to produce chalky white area.

*Calcium deposition around the inflammatory border for eg. – Acute pancreatitis

5) Fibrinoid Necrosis :-

Deposition of fibrin like material

Commonly seen in immune complex mediated vasculitis for eg.- Auto immune disease, Vasculitis peptic ulcer.

Comments

Post a Comment

Popular posts from this blog

Introduction to cell injury and it's Causes

 Introduction to cell injury and it's Causes. Definition of cell injury- Cell injury defined as the effect of a variety of stress due to etiological agents a cell encounters resulting in change in its internal and external environmental. ↬ cells actively interact with their environment, constantly adjusting their structure and function to accommodate/ adopt changing demands and extracellular stresses. where as stress means increase work load in heart.  ↬ Intracellular substance of the cells is normally tightly regulated such as Homeostasis ↬ As cells encounter physiologic stresses or potentially injurious conditions(such as nutrient deprivation) ↬ when body cell are exposed to antigen then they have inbuilt mechanism to deal with change in environment or adaptation but cellular injury occurs when a stress exceeds the cells can not ability to adopt. Cellular adaptation- The cells of our body they have the power or capacity to a response to stressful by changin...
Post a Comment
Read more

उपशाया/अनुपशाय

     १. गूढ़ लिङ्गं व्याधिमुपशयानुपशयाभ्यां परीक्षेत्।। (च.वि. ४/८)          किसी व्याधि के लक्षण अति अल्प हो अथवा छुपे हुये हो तो रोगों का निदान (Diagnosis) उपशय व अनुपशय द्वारा किया जाता है। गूढ़ लिङ्ग व्याधियों की परीक्षा 'उपशय-अनुपशय' द्वारा की जाती है। जैसे- शोथ स्नेहन, उष्ण उपचार तथा मर्दन से शांत होता है स्नेहनादि को उपशय कहते हैं।           २.    हेतु व्याधिविपर्यस्तविपर्यस्तकारिणाम्।                  औषधान्न विहारणामुपयोगं सुखावहम्।।                  विद्यादुपशयं व्याधेः सहि सात्म्यमिति स्मृतः।                 विपरीतोऽनुपशयो व्याध्यसात्म्यमिति स्मृतः।। (अ.ह.नि. १/६-७)   उपशय:- उपशय का अर्थ है चिकित्सीय परीक्षण या मार्गदर्शन और प्राचीन आयुर्वेद की नैदानिक ​​कला में नैदानिक ​​उद्देश्यों के लिए उपयोग किया जाता था। "औषध अन्ना विहरनम उपयोगम सुखावाहम्" का अर्थ है ...
Post a Comment
Read more

Oedema

  Definition of brief description    of Edema ,Shock ,Haemorrage Embolism ,Ischemia & Infarction:- Oedema :- Excess fluid in the body tissue (extra vascularly ) means (excess fluid in the body either inside the cells which is intracellular edema either or in the interstitium in the body cavity which is called extra cellular edema .                                                  Or Edema is defined as abnormal & excessive accumulation of “free fluid” in interstitial tissue space and serous cavities. Free fluid in interstitial fluid- ·           It is also called tissue space ·           Its surrounded by tissue cells ·    ...
Post a Comment
Read more